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A white serving bowl filled with creamy shrimp and rice casserole, topped with melted cheese, peas, and fresh herbs.

4-Ingredient Slow Cooker Seafood Casserole

This incredibly easy 4-ingredient slow cooker seafood casserole delivers a creamy, comforting meal with minimal effort. Perfect for a busy weeknight, it combines frozen seafood, condensed soup, vegetables, and cream cheese into a hearty dish.
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Prep Time 10 minutes
Cook Time 4 hours
Total Time 4 hours 10 minutes
Servings: 6 servings
Course: Main Course
Cuisine: American
Calories: 520
Ingredients Equipment Method Notes

Ingredients
  

  • 1.5 lbs Frozen Mixed Seafood shrimp, scallops, calamari, mussels, or fish pieces, no need to thaw
  • 2 cans Condensed Cream of Mushroom Soup 10.5 oz / 298g each, undiluted
  • 1 bag Frozen Mixed Vegetables 16 oz / 454g, such as peas, carrots, corn, green beans, no need to thaw
  • 8 oz Cream Cheese full-fat or reduced-fat, cut into 1-inch cubes

Equipment

  • 6-quart (or larger) Slow Cooker
  • Large Mixing Bowl
  • Spatula or wooden spoon

Method
 

  1. Lightly grease the inside of your 6-quart (or larger) slow cooker with cooking spray or butter.
  2. In a large mixing bowl, combine the frozen mixed seafood, condensed cream of mushroom soup, and frozen mixed vegetables. Stir gently to ensure everything is coated.
  3. Pour the mixture into the prepared slow cooker. Distribute the cubed cream cheese evenly over the top of the seafood and vegetable mixture.
  4. Cover the slow cooker and cook on LOW for 3-4 hours, or on HIGH for 1.5-2 hours. The casserole is ready when the seafood is cooked through, opaque, and flaky, and the vegetables are tender.
  5. Before serving, give the casserole a good stir to incorporate the melted cream cheese and create a rich, creamy sauce. Serve hot.

Notes

Serve this hearty seafood casserole over rice, pasta, mashed potatoes, or with crusty bread for soaking up the delicious sauce. For a touch more flavor, you can add a pinch of black pepper or a dash of old bay seasoning, though it's excellent as is with just 4 ingredients. Leftovers can be stored in an airtight container in the refrigerator for up to 2-3 days and reheated gently.